Novel Cocrystal Structures of Peptide Antagonists Bound to the Human Melanocortin Receptor 4 Unveil Unexplored Grounds for Structure-Based Drug Design
Melanocortin 4 receptor (MC4-R) antagonists are actively sought for treating cancer cachexia. We determined the structures of complexes with PG-934 and SBL-MC-31 . These peptides differ from SHU9119 by substituting His 6 with Pro 6 and inserting Gly 10 or Arg 10 .
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Sustained release of a human PD-L1 single-domain antibody using peptide-based hydrogels
Abstract Monoclonal antibodies (mAbs) targeting the immune checkpoint axis, which contains the programmed cell death protein-1 (PD-1) and its ligand PD-L1, revolutionized the field of oncology.
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Vacature technisch expert
Technisch expert - Organische chemie, vakgroepen Chemie en Bio-ingenieurswetenschappen Categorie: Management & Professionals 1 - Werken bij de VUB Ben jij onze Technisch Expert Ingenieur die graag uitkijkt naar e...
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Vacature technisch expert
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ORGC is Recipient of Innoviris Proof-of-Concept Funding to screen a small-molecule library for application in pancreatic cancer
At the start of November, ORGC became the recipient of Innoviris (Brussels Capital Region) proof-of-concept funding to undertake a high-throughput screening of a commercial small molecule library to discovery lead compounds for further medicinal chemistry work.
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ORGC Receives FWO Project funding to develop G protein Peptidomimetics
On December 13th, the FWO announced the results of this year’s applications for Junior and Senior Research Projects.
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ORGC Receives FWO Project funding to develop inhibitors of a viral protein-protein interaction
On December 13th, the FWO announced the results of this year’s applications for WEAVE Research Projects with various partner countries and regions. ORGC – alongside our partner Dr.
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Another award for ORGC!
At the 15th Australian Peptide Conference 🇦🇺 and 13th International Peptide Symposium! 🌏 in Brisbane, our phenomenal student Debora was honoured with first place in the 13th IPS Poster Award supported by Mimotopes, recognising her outstanding PhD research.
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Structure-Based Design and Synthesis of Stapled 10Panx1 Analogues for Use in Cardiovascular Inflammatory Diseases
Lamouroux, A.; Tournier, M.; Iaculli, D.; Caufriez, A.; Rusiecka, O.M.; Martin, C.; Bes, V.; Carpio, L.E.; Girardin, Y.; Loris, R.; Tabernilla, A.; Molica, F.; Gozalbes, R.; Mayán, M.D.; Vinken, M.; Kwak, B.R.; Ballet, S.; J. Med. Chem. 2023, 66, 18, 13086–13102
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Smart hydrogels delivered by high pressure aerosolization can prevent peritoneal adhesions
Braet, H.; Fransen, P.-P.; Chen, Y.; Van Herck, S.; Mariën, R.; Vanhoorne, V.; Ceelen, W.; Madder, A.; Ballet, S.; Hoogenboom, R.; De Geest, B.; Hoorens, A.; Dankers, P.Y.W.; De Smedt, S.C.; Remaut, K.; J. Control Release, 2023, 362, 138-150
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