Second generation Spautin-1 analogues targeting EGFR-mutant non-small cell lung cancer cells
Elsocht, M., Giron, P., De Grève, J., Ballet, S. Bioorg. Med. Chem Lett. 2023, 79, 129066.
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Propargylamine Amino Acids as Constrained Nε‑Substituted Lysine Mimetics
Herein, alkylated propargylamines are reported as constrained lysine mimetics and constructed in a single step using a copper(I)-catalyzed A3-coupling reaction.
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Opening the amino acid toolbox for peptide-based NTS2-selective ligands as promising lead compounds for pain management
Chronic pain is one of the most critical health issues worldwide. Despite considerable efforts to find therapeutic alternatives, opioid drugs remain the gold standard for pain management.
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Bifunctional Peptidomimetic G Protein-Biased Mu-Opioid Receptor Agonist and Neuropeptide FF Receptor Antagonist KGFF09 Shows Efficacy in Visceral Pain without Rewarding Effects after Subcutaneous Administration in Mice
There is still an unmet clinical need to develop new pharmaceuticals for effective and safe pain management. Current pharmacotherapy offers unsatisfactory solutions due to serious side effects related to the chronic use of opioid drugs.
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Bifunctional Peptidomimetic G Protein-Biased Mu-Opioid Receptor Agonist and Neuropeptide FF Receptor Antagonist KGFF09 Shows Efficacy in Visceral Pain without Rewarding Effects after Subcutaneous Administration in Mice
There is still an unmet clinical need to develop new pharmaceuticals for effective and safe pain management. Current pharmacotherapy offers unsatisfactory solutions due to serious side effects related to the chronic use of opioid drugs.
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Impact of doubling peptide length on in vivo hydrogel stability and sustained drug release
Heremans, J., Chevillard, L., Mannes, M., Mangialetto, J., Leroy, K., White, J.F., Lamouroux, A., Vinken, M., Gardiner, J., Van Mele, B. and Van den Brande, N., Hoogenboom, R., Madder, A., Caveliers, V., Mégarbane, B., Hernot, S., Ballet, S., Martin, C., J. Controlled Release, 2022, 350, 514-524.
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Impact of doubling peptide length on in vivo hydrogel stability and sustained drug release
Heremans, J.; Chevillard, L.; Mannes, M.; Mangialetto, J.; Leroy, K; White, J.F.; Lamouroux, A.; Vinken, M.; Gardiner, J.; Van Mele, B.; Van den Brande, N.; Hoogenboom, R.; Madder, A.; Caveliers, V.; Mégarbane ,B.; Hernot, S.; Ballet, S.; Martin, C., Journal of Controlled Release, 2022,350, 514-524
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ORGC brings home the prices at EPS
What a fantastic result for ORGC! 🎊 At this year's European Peptide Symposium, which was held last week in Sitges, two of our talented researchers were recognised: our very own Julie Heremans won the 2nd Prize 🏅 in the Dr. Bert and Dr.
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A Quantum Chemical Deep-Dive into the pi-pi Interactions of 3-Methylindole and Its Halogenated Derivatives—Towards an Improved Ligand Design and Tryptophan Stacking
Van Lommel, R.; Bettens, T.; Barlow, T.M.A.; Bertouille, J.; Ballet, S.; De Proft, F. Pharmaceuticals 2022, 15, 935. https://doi.org/10.3390/ph15080935
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Dr. Mannes wins best oral communication at GFPP-BPGM
A huge congratulations to our talented researcher Dr. Mannes, who, last week, won best oral communication for her presentation on her PhD research at this year's French-Belgian Joint Meeting of peptide and protein research groups in Port Leucate.
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Our review on peptides as allosteric protein modulators made the cover!
We are trilled to announce that our review that wanders beyond small molecules and focusses on peptides as allosteric protein modulators is featured on the cover of Trends in Pharmacological Sciences. For a full read, click here.
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