Two papers in Nature revealing the receptor activation mechanism for opioid and morphinan analgesics

An international team of scientists amongst whom Jan Steyaert and Toon Laeremans (VIB/Vrije Universiteit Brussel) have unraveled the structural basis for mORactivation. In two Nature papers, they report on the X-ray and NMR structures of the agonist-bound mOR receptor, stabilized in its fully activated state by use of a G protein mimetic camelid antibody fragment. Read more