Engineering Nanobodies for Structural Biology, Molecular Pharmacology and Drug Discovery

We pioneered the use of Nanobodies in X-ray crystallography and cryo-EM, aiming at the highest hanging fruits in structural biology including membrane proteins, amyloidogenic proteins, and  (transient) multiprotein complexes. 

We engineer Nanobodies to be used as research tools in biotechnology and molecular pharmacology.

We discover Nanobodies that modulate the function of difficult targets to develop first-in-class drugs.