Molecular structure:
Nocodazole or methyl[5-(2-thienyl-carbonyl)-1H-benzimidazol-2-yl]-carbamate is one of the antimicrotubule agents used as an antitumor drug. It inhibits the polymerisation of free tubuline molecules by binding an arginine residu of the ß-tubulin subunit.
Reference:
Decordier I., Dillen L., Cundari E., Kirsch-Volders M. "Elimination of micronucleated cells by apoptosis after treatment with inhibitor of microtubules" Mutagenesis, 2002, 17(4): 337-344