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Molecular machines

The goal of our research is to understand how biological molecular machines work. We use single particle cryogenic electron microscopy (cryo-EM) to solve high-resolution structures of molecular machines and visualise protein conformations associated with their function. In order to advance beyond state of the art we invest efforts in developing new approaches for preparation of cryo-EM samples using microfluidics. We are an interdisciplinary team consisting of structural biologists and engineers working together towards understand how incredibly efficient and versatile molecular machines evolved by within living organisms work.  

Rouslan
©Inge Dehandschutter

Rouslan Efremov

VIB group leader since 2015

2005 PhD Research Centre Jülich (Germany) and MIPT (Moscow)  

2006 Postdoc MRC Mitochondrial Biology Unit (Cambridge, UK)

2011 Postdoc Max Planck Institute of Molecular Physiology (Dortmund, Germany)

Latest publications

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P Kolata, RG Efremov, Structure of Escherichia coli respiratory complex I reconstituted into lipid nanodiscs reveals an uncoupled conformation. eLife 2021;10:e68710 DOI: 10.7554/eLife.68710

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Efremov R.G., Stroobants A, Coma-corrected rapid single-particle cryo-EM data collection on the CRYO ARM 300, Acta Cryst D, 2021, 77:5 DOI 10.1107/S2059798321002151