Steven BALLET
Vrije Universiteit Brussel
Room 9G618
Pleinlaan 2
1050 Brussels | Belgium
Dr. Steven Ballet completed his PhD (Topic: Synthesis of aminobenzazepinones for application in peptidomimetics; promotor: Prof. Dirk Tourwé) at the Vrije Universiteit Brussel (VUB, Brussels, Belgium) in 2007. Directly following his PhD training, Dr Ballet went for a first postdoctoral stay in Australia at the University of Adelaide with Professor Andrew Abell. During this stay he applied ring closing and cross metathesis reactions on amino acid and peptide substrates. As such, dimeric but also ring closed peptide scaffolds could be obtained. More specifically, RCM was used to stabilize ('staple') the helical conformation of alpha and beta peptides. As a second postoctoral training, Dr. Ballet went to the Institut de Recherches Cliniques de Montréal (Montreal, Canada) for a specialized training in the opioid peptide field. Together with Prof. Peter W. Schiller, he designed bifunctional opioid ligands with dual MOR/DOR agonist profiles and hybrid opioid/non-opioid multitarget ligands. Since 2010 Dr. Ballet is appointed as a faculty member at his alma mater, the Vrije Universiteit Brussel, where he pursues his efforts in the peptide and peptidomimetic field.
2018
Jida, M., & Ballet, S. (2018). An Efficient One-Pot Synthesis of Chiral N-Protected 3-Substituted (Diketo)piperazines via Ugi-4CR/De-Boc/Cyclization Process. ChemistrySelect, 3(4), 1027-1031.
Chevillard, F., Rimmer, H., Betti, C., Pardon, E., Ballet, S., van Hilten, N., ... Kolb, P. (2018). Binding-Site Compatible Fragment Growing Applied to the Design of β2-Adrenergic Receptor Ligands. Journal of Medicinal Chemistry, 61(3), 1118-1129.
De Prins, A., Martin, C., Van Wanseele, Y., Skov, L. J., Tömböly, C., Tourwe, D., ... Ballet, S. (2018). Development of potent and proteolytically stable human neuromedin U receptor agonists. European Journal of Medicinal Chemistry, 144, 887-897.
De Prins, A., Martin, C., Van Wanseele, Y., Tömböly, C., Tourwe, D., Caveliers, V., ... Ballet, S. (2018). Discovery of potent NMUR1 selective Neuromedin U analogs with increased resistance against biodegradation. Poster session presented at Belgian Peptide Group Meeting 2018, Brussels, Belgium.
Crauwels, M., Massa, S., Martin, C., Ballet, S., D'Huyvetter, M., Hernot, S., ... Xavier, C. (2018). Effect of charges on the kidney retention of site-specific labelled Nanobodies. Poster session presented at Belgian Peptide Group Meeting 2018, Brussels, Belgium.
Crauwels, M., Massa, S., Betti, C., Martin, C., Ballet, S., D'Huyvetter, M., ... Xavier, C. (2018). Effect of Nanobody-based radiopharmaceuticals on kidney retention. Poster session presented at European Molecular Imaging Meeting - EMIM 2018, San Sebastian (Donostia), Spain.
Jida, M., & Ballet, S. (2018). Efficient one-pot synthesis of enantiomerically pure: N -protected-α-substituted piperazines from readily available α-amino acids. New Journal of Chemistry, 42(3), 1595-1599.
Pardon, E., Betti, C., Laeremans, T., Chevillard, F., Guillemyn, K., Kolb, P., Ballet, S., Steyaert, J. (2018). Nanobody-enabled reverse pharmacology on GPCRs. Angewandte Chemie International Edition.
Van der Poorten, O., Van Den Hauwe, R., Hollanders, K., Tourwé, D., Jida, M., & Ballet, S. (2018). Rapid construction of substituted 3-amino-1,5-benzothiazepin-4(5H)-one dipeptide scaffolds through an Ugi-4CR - Ullmann cross-coupling sequence. Organic & Biomolecular Chemistry, 16(8), 1242-1246.
Crauwels, M., Massa, S., Martin, C., Betti, C., Ballet, S., Devoogdt, N., ... Muyldermans, S. (2018). Site-specific radioactive labelling of Nanobodies. In Site-specific radioactive labelling of Nanobodies
Wybon, C. C. D., Mensch, C., Hollanders, K., Gadais, C., Herrebout, W. A., Ballet, S., & Maes, B. U. W. (2018). Zn-Catalyzed tert-Butyl Nicotinate-Directed Amide Cleavage as a Biomimic of Metallo-Exopeptidase Activity. ACS Catalysis, 8(1), 203-218.
2017
Zhu, Y-P., Mampuys, P., Sergeyev, S., Ballet, S., & Maes, B. U. W. (2017). Amine Activation: N-Arylamino Acid Amide Synthesis from Isothioureas and Amino Acids. Advanced Synthesis & Catalysis, 359(14), 2481-2498.
Starnowska, J., Costante, R., Guillemyn, K., Popiolek-Barczyk, K., Chung, N. N., Lemieux, C., Ballet, S., ... Przewlocka, B. (2017). Analgesic Properties of Opioid/NK1 Multitarget Ligands with Distinct in Vitro Profiles in Naive and Chronic Constriction Injury Mice. ACS Chemical Neuroscience.
Raaymakers, C., Verbrugghe, E., Hernot, S., Hellebuyck, T., Betti, C., Peleman, C., Ballet, S., ... Roelants, K. (2017). Antimicrobial peptides in frog poisons constitute a molecular toxin delivery system against predators. Nature Communications, 8(1), 1495.
Starnowska, J., Guillemyn, K., Makuch, W., Mika, J., Ballet, S., & Przewlocka, B. (2017). Bifunctional opioid/nociceptin hybrid KGNOP1 effectively attenuates pain related behaviour in a rat model of neuropathy. European Journal of Pharmaceutical Sciences, 104, 221-229.
Lagard, C., Chevillard, L., Guillemyn, K., Risède, P., Laplanche, J-L., Spetea, M., Ballet, S., ... Mégarbane, B. (2017). Bifunctional peptide-based opioid agonist/nociceptin antagonist ligand for dual treatment of nociceptive and neuropathic pain. Pain, 158(3), 505-515.
Barlow, T. M. A., Tourwé, D., & Ballet, S. (2017). Cyclisation To Form Small, Medium and Large Rings by Use of Catalysed and Uncatalysed Azide–Alkyne Cycloadditions (AACs). European Journal of Organic Chemistry, 2017(32), 4678-4694.
De Prins, A., Martin, C., Van Wanseele, Y., Tömböly, C., Tourwe, D., Caveliers, V., ... Ballet, S. (2017). Development of potent and receptor subtype selective neuromedin U analogs. Poster session presented at PhD day C4N, .
Dyniewicz, J., Lipinski, P. F. J., Kosson, P., Lesniak, A., Bochynska-Czyz, M., Muchowska, A., Ballet, S., ... Lipkowski, A. W. (2017). Hydrazone Linker as a Useful Tool for Preparing Chimeric Peptide/Nonpeptide Bifunctional Compounds. ACS Medicinal Chemistry Letters, 8(1), 73-77.
Oyen, E., Martin, C., Caveliers, V., Madder, A., Van Mele, B., Hoogenboom, R., ... Ballet, S. (2017). In Vivo Imaging of the Stability and Sustained Cargo Release of an Injectable Amphipathic Peptide-Based Hydrogel. Biomacromolecules, 18(3), 994-1001.
Martin, C., Oyen, E., Van Wanseele, Y., Ben Haddou, T., Schmidhammer, H., Andrade, J., ... Ballet, S. (2017). Injectable peptide-based hydrogel formulations for the extended in vivo release of opioids. Materials Today Chemistry, 3, 49-59.
Ballet, S. (2017). New opioids to limit toxicity: Where are we going? Toxicology Letters, 280, S43-S43.
Martin, C., Moors, S. L. C., Danielsen, M., Betti, C., Fabris, C., Pedersen, D. S., ... Ballet, S. (2017). Rational Design of Nanobody80 Loop Peptidomimetics: Towards Biased beta(2) Adrenergic Receptor Ligands. Chemistry - a European Journal, 23(40), 9632-9640.
Crauwels, M., Massa, S., Ballet, S., Betti, C., Martin, C., D'Huyvetter, M., ... Xavier, C. (2017). Sortase as a tool to produce nanobody based radiopharmaceuticals for theranostics. Poster session presented at Symposium 'Molecular Imaging Agents in Medicine', Groningen, Netherlands.
Crauwels, M., Massa, S., Ballet, S., Betti, C., Martin, C., D'Huyvetter, M., ... Xavier, C. (2017). Sortase as a tool to produce nanobody based radiopharmaceuticals for theranostics. Poster session presented at 22nd International Symposium on Radiopharmaceutical Sciences, Dresden, Germany.
Van der Poorten, O., Van Den Hauwe, R., Eiselt, E., Betti, C., Guillemyn, K., Chung, N. N., ... Ballet, S. (2017). χ-Space Screening of Dermorphin-Based Tetrapeptides through Use of Constrained Arylazepinone and Quinolinone Scaffolds. ACS Medicinal Chemistry Letters, 8(11), 1177-1182.
De Prins, A., De Bundel, D., Van Eeckhaut, A., Ballet, S., & Smolders, I. (2017). The effects of neuromedin U on stress-related behavior and neuronal activation. Poster session presented at C4N PhD day, Brussels, Belgium.
Willemse, T., Schepens, W., van Vlijmen, H. W. T., Maes, B. U. W., & Ballet, S. (2017). The Suzuki-Miyaura Cross-Coupling as a Versatile Tool for Peptide Diversification and Cyclization. Catalysts, 7(3).
Gadais, C., Hollanders, K., Moors, S., Fehér, K., Pytkowics, J., Martins, J. C., ... Ballet, S. (2017). Trifluoromethylated proline surrogates as part of “Pro-Pro” turninducing templates for the design of β-hairpin mimetics.
2016
Lagard, C., Chevillard, L., Risede, P., Megarbane, B., & Ballet, S. (2016). A bifunctional and peptide-based opioid agonist-nociceptin antagonist ligand for treatment of pain: is the benefit-to-neurorespiratory toxicity ratio improved compared to the usual opioids? Clinical Toxicology, 54(4), 416-417.
Guillemyn, K., Starnowska, J., Lagard, C., Dyniewicz, J., Rojewska, E., Mika, J., ... Ballet, S. (2016). Bifunctional Peptide-Based Opioid Agonist Nociceptin Antagonist Ligands for Dual Treatment of Acute and Neuropathic Pain. Journal of Medicinal Chemistry, 59(8), 3777-3792.
Kowalczyk, A., Kleczkowska, P., Rekawek, M., Kulik, K., Lesniak, A., Erdei, A., ... Bujalska-Zadrozny, M. (2016). Biological evaluation and molecular docking studies of AA3052, a compound containing a mu-selective opioid peptide agonist DALDA and D-Phe-Phe-D-Phe-Leu-Leu-NH2, a substance P analogue. European Journal of Pharmaceutical Sciences, 93, 11-20.
Starnowska, J., Guillemyn, K., Betti, C., Makuch, W., Ballet, S., Mika, J., & Przewlocka, B. (2016). COMPARISON OF ANALGESIC ACTION OF NOVEL OPIOID-NK1R BIFUNCTIONAL LIGANDS IN ACUTE AND NEUROPATHIC PAIN IN MICE. Journal of Neuroimmune Pharmacology, 11, S45-S45.
Knuhtsen, A., Legrand, B., Van der Poorten, O., Amblard, M., Martinez, J., Ballet, S., ... Pedersen, D. S. (2016). Conformationally Constrained Peptidomimetics as Inhibitors of the Protein Arginine Methyl Transferases. Chemistry - a European Journal, 22(39), 14022-14028.
Martin, C., De Baerdemaeker, A., Poelaert, J., Madder, A., Hoogenboom, R., & Ballet, S. (2016). Controlled-release of opioids for improved pain management. Materials Today, 19(9), 491-502.
De Prins, A., Betti, C., Sivertsen, B., Caveliers, V., Van Eeckhaut, A., Holst, B., ... Smolders, I. J. (2016). Development and in vitro characterization of neuromedin U analogues. Poster session presented at Belgian Peptide Group Meeting 2016, Brussels, Belgium.
De Prins, A., Martin, C., Caveliers, V., Van Eeckhaut, A., Tömböly, C., Rosenkilde, M. M., ... Ballet, S. (2016). Development of potent neuromedin U receptor agonists. 12. Abstract from 19th Forum of Pharmaceutical Sciences, Brussels, Belgium.
De Prins, A., Martin, C., Caveliers, V., Van Eeckhaut, A., Holst, B., Smolders, I., & Ballet, S. (2016). Development of potent neuromedin U receptor agonists. Poster session presented at 34th European Peptide Symposium 2016, Leipzig, Germany.
Barlow, T., Jida, M., Guillemyn, K., Tourwe, D., & Ballet, S. (2016). EFFICIENT ONE-POT SYNTHESIS OF AMINO-BENZOTRIAZOLODIAZOCINONE SCAFFOLDS VIA CATALYST-FREE TANDEM UGI-HUISGEN REACTIONS. Journal of Peptide Science, 22, S56-S56.
Barlow, T. M. A., Jida, M., Guillemyn, A. K., Tourwe, D., Caveliers, V., & Ballet, S. (2016). Efficient one-pot synthesis of amino-benzotriazolodiazocinone scaffolds via catalyst-free tandem Ugi-Huisgen reactions. Organic & Biomolecular Chemistry, 14(20), 4669-4677. DOI: 10.1039/c6ob00438e
Van der Poorten, O., Legrand, B., Vezenkov, L. L., Martinez, J., Bettache, N., Garcia, M., ... Ballet, S. (2016). INDOLOAZEPINONE-CONTAINING OLIGOMERS AS CELL-PENETRATING (NON)PEPTIDES: SYNTHESIS, STRUCTURATION AND INTERNALIZATION. Journal of Peptide Science, 22, S116-S116.
Oyen, E., Martin, C., Hernot, S., Gardiner, J., Van Mele, B., Madder, A., ... Ballet, S. (2016). INJECTABLE PEPTIDE HYDROGELS FOR CONTROLLED DRUG RELEASE. Journal of Peptide Science, 22, S84-S84.
Martin, C., Oyen, E., Mangelschots, J., Bibian, M., Ben Haddou, T., Andrade, J., ... Ballet, S. (2016). Injectable peptide hydrogels for controlled-release of opioids. MedChemComm, 7(3), 542-549. DOI: 10.1039/C5MD00440C
Mangelschots, J., Bibian, M., Gardiner, J., Waddington, L., Van Wanseele, Y., Van Eeckhaut, A., ... Ballet, S. (2016). Mixed α/β-Peptides as a Class of Short Amphipathic Peptide Hydrogelators with Enhanced Proteolytic Stability. Biomacromolecules, 17(2), 437-445. DOI: 10.1021/acs.biomac.5b01319
Betti, C., Krummenacher, S., Martin, C., Boeglin, J., Xavier, C., Devoogdt, N., ... Ballet, S. (2016). NANOBODY CDR3 PEPTIDOMIMETICS AS EGFR-POSITIVE CANCER DIAGNOSTICS. Journal of Peptide Science, 22, S214-S214.
Willemse, T., Van Vlijmen, H., Schepens, W., Maes, B., & Ballet, S. (2016). PALLADIUM-CATALYSED DERIVATISATION OF PEPTIDES IN AN AQUEOUS ENVIRONMENT. Journal of Peptide Science, 22, S76-S76.
Van der Poorten, O., Knuhtsen, A., Pedersen, D. S., Ballet, S., & Tourwe, D. (2016). Side Chain Cyclized Aromatic Amino Acids: Great Tools as Local Constraints in Peptide and Peptidomimetic Design. Journal of Medicinal Chemistry, 59(24), 10865-10890. DOI: 10.1021/acs.jmedchem.6b01029
Massa, S., Vikani, N., Betti, C., Ballet, S., Vanderhaegen, S., Steyaert, J., ... Devoogdt, N. (2016). Sortase A-mediated site-specific labeling of camelid single-domain antibody-fragments: a versatile strategy for multiple molecular imaging modalities. Contrast Media & Molecular Imaging, 11(5), 328-339. DOI: 10.1002/cmmi.1696
Crauwels, M., Massa, S., Ballet, S., Betti, C., Martin, C., D'Huyvetter, M., ... Xavier, C. (2016). Sortase as a tool to produce nanobody-based radiopharmaceuticals for theranostics. Poster session presented at MedChem, Mont-Saint-Guibert, Belgium.
Tóth, F., Mallareddy, J. R., Tourwé, D., Lipkowski, A. W., Bujalska-Zadrozny, M., Benyhe, S., ... Kleczkowska, P. (2016). Synthesis and binding characteristics of [3H]neuromedin N, a NTS2 receptor ligand. Neuropeptides, 57, 15. DOI: 10.1016/j.npep.2015.12.004
Verlinden, S., Ballet, S., & Verniest, G. (2016). SYNTHESIS AND TRANSFORMATIONS OF 1,3-DIYNE CONTAINING TETRAPEPTIDES. Journal of Peptide Science, 22, S74-S74.
Verlinden, S., Ballet, S., & Verniest, G. (2016). Synthesis of Heterocycle-Bridged Peptidic Macrocycles through 1,3-Diyne Transformations. European Journal of Organic Chemistry, (35), 5807-5812. DOI: 10.1002/ejoc.201601215
Halle, F., Van der Poorten, O., Doebelin, C., Niederst, M., Schneider, S., Schmitt, M., ... Bihel, F. (2016). Synthesis of 3-amino-3,4-dihydro-1H-quinolin-2-ones through regioselective palladium-catalyzed intramolecular cyclization. Tetrahedron Letters, 57(14), 1547-1550. DOI: 10.1015/j.tetlet.2016.02.094
Martin, C., Betti, C., Fabris, C., Mathiesen, J. M., Pardon, E., Peyressatre, M., ... Ballet, S. (2016). TOWARDS B-ARRESTIN BIASED B2AR LIGANDS: RATIONAL DESIGN OF NANOBODY LOOP MIMETICS. Journal of Peptide Science, 22, S134-S134.
2015
Ballet, S., Guillemyn, K. J., Van Der Poorten, O., Schurgers, B., Verniest, G., & Tourwe, D. (2015). Azepinone-constrained Amino Acids in Peptide And Peptidomimetic Design. In Azepinone-constrained Amino Acids in Peptide And Peptidomimetic Design
Van der Poorten, O., Fehér, K., Buysse, K., Feytens, D., Zoi, I., Schwartz, S. D., ... Ballet, S. (2015). Azepinone-Containing Tetrapeptide Analogues of Melanotropin Lead to Selective hMC4R Agonists and hMC5R Antagonist. ACS Medicinal Chemistry Letters, 6(2), 192-197. DOI: 10.1021/ml500436s
De Prins, A., Betti, C., Sivertsen, B., Caveliers, V., Van Eeckhaut, A., Holst, B., ... Smolders, I. (2015). Development and in vitro characterization of neuromedin U analogues.. Poster session presented at IVth PhD day @ Jette, Vrije Universiteit Brussel, Belgium, 31 March 2015, Belgium.
De Prins, A., Betti, C., Sivertsen, B., Caveliers, V., Van Eeckhaut, A., Holst, B., ... Smolders, I. (2015). Development and in vitro characterization of neuromedin U analogues.. Poster session presented at 4th PhD Day Research Unlimited, Jette, Belgium.
Betti, C., Starnowska, J., Mika, J., Dyniewicz, J., Frankiewicz, L., Novoa, A., ... Ballet, S. (2015). Dual Alleviation of Acute and Neuropathic Pain by Fused Opioid Agonist-Neurokinin 1 Antagonist Peptidomimetics. ACS Medicinal Chemistry Letters, 6(12), 1209-1214. DOI: 10.1021/acsmedchemlett.5b00359
Verlinden, S., Geudens, N., Martins, J. C., Tourwe, D., Ballet, S., & Verniest, G. (2015). Oxidative alpha,omega-diyne coupling as an approach towards novel peptidic macrocycles. Organic & Biomolecular Chemistry, 13(36), 9398-9404. DOI: 10.1039/c5ob01153a
Bibian, M., Mangelschots, J., Gardiner, J., Waddington, L., Acevedo, M. M. D., De Geest, B. G., ... Ballet, S. (2015). Rational design of a hexapeptide hydrogelator for controlled-release drug delivery. Journal of Materials Chemistry B, 3(5), 759-765. DOI: 10.1039/c4tb01294a
Massa, S. M., Vikani, N. A., Gorsen, S., Vanderhaegen, S., Steyaert, J., Bartz, C., ... Devoogdt, N. (2015). Sortase-mediated site-specific labeling of nanobodies: A generic method for multiple imaging modalities. In WMIC 2015 WMIS.
Xavier, C., Massa, S. M., Vikani, N. A., Gorsen, S., Vanderhaegen, S., Betti, C., ... Devoogdt, N. (2015). Sortase-mediated site-specific labeling of Nanobodies for use in molecular imaging. In BMIC 2015
Massa, S., Vikani, N. A., Vanderhaegen, S., Betti, C., Ballet, S., Caveliers, V., ... Xavier, C. (2015). Sortase-mediated site-specific labeling of Nanobodies for use in molecular imaging. In EMIM 2015
Massa, S. M., Vikani, N. A., Gorsen, S., Vanderhaegen, S., Betti, C., Ballet, S., ... Xavier, C. (2015). Sortase-mediated site-specific labeling of nanobodies for use in molecular imaging. Poster session presented at Belgian Society of Nuclear Medicine (BELNUC) Congress 2015, Maastricht, Netherlands.
Fenalti, G., Zatsepin, N., Betti, C., Giguere, P., Han, G. W., Ishchenko, A., ... Cherezov, V. (2015). Structural basis for bifunctional peptide recognition at human delta-opioid receptor. Nature Structural and Molecular Biology, 22(3), 265-268. DOI: 10.1038/nsmb.2965
Willemse, T., Van Imp, K., Goss, R. J. M., Van Vlijmen, H. W. T., Schepens, W., Maes, B. U. W., & Ballet, S. (2015). Suzuki-Miyaura Diversification of Amino Acids and Dipeptides in Aqueous Media. ChemCatChem, 7(14), 2055-2070. DOI: 10.1002/cctc.201500190
Guillemyn, K., Tourwe, D., & Ballet, S. (2015). Synthesis and biological evaluation of compact, conformationally constrained bifunctional opioid agonist – Neurokinin-1 antagonist peptidomimetics. European Journal of Medicinal Chemistry, 92, 64-77.
Jida, M., Van der Poorten, O., Guillemyn, K., Urbanczyk-Lipkowska, Z., Tourwe, D., & Ballet, S. (2015). T3P-Promoted, Mild, One-Pot Syntheses of Constrained Polycyclic Lactam Dipeptide Analogues via Stereoselective Pictet-Spengler and Meyers Lactamization Reactions. Organic Letters, 17(18), 4482-4485. DOI: 10.1021/acs.orglett.5b02145
Jida, M., Van Der Poorten, O., Guillemyn, K., Urbanczyk-Lipkowska, Z., Tourwé, D., & Ballet, S. (2015). T3P-promoted, mild one-pot syntheses of constrained polycyclic lactam dipeptide analogues via stereoselective Pictet-Spengler and Meyers’ lactamization reactions. Organic Letters, 17(18), 4482-4485.
2014
Lumeng, Y., Hildebrand, F., Dingemans, J., Ballet, S., Laus, G., Matthijs, S., ... Cornelis, P. (2014). Draft genome sequence analysis of a Pseudomonas putida W15Oct28 strain with antagonistic activity to Gram-positive and Pseudomonas sp. pathogens. PLoS ONE, 9(11), [e110038].
Barlow, T., & Ballet, S. (2014). Efficient synthesis of conformationally constrained, amino-triazoloazepinone-containing di- and tripeptides via a one-pot Ugi-Huisgen tandem reaction. Organic & Biomolecular Chemistry, 12, 6986-6989.
Jida, M., Tourwe, D., & Ballet, S. (2014). Highly stereoselective one-pot construction of trisubstituted tetrahydro-beta-carboline-fused diketopiperazines: a synthetic route towards cialis analogues. RSC Advances, 4, 38159-38163.
Betti, C., Novoa, A., Toemboely, C., Nielsen, C. U., Helms, H. C., Lesniak, A., ... Ballet, S. (2014). IN VITRO MEMBRANE PERMEATION STUDIES AND IN VIVO ANTINOCICEPTION OF GLYCOSYLATED Dmt(1)-DALDA ANALOGUES. Journal of Peptide Science, 20(s1), S165-S166. [P087].
Ballet, S. (2014). In Vitro Membrane Permeation Studies and in Vivo Antinociception of Glycosylated Dmt(1)-DALDA Analogues. ACS Medicinal Chemistry Letters, 5, 352-357.
Ballet, S., Betti, C., Novoa, A., Tömböly, C., Helms, C., Lesniak, A., ... Schiller, P. (2014). In Vitro Membrane Permeation Studies and in Vivo Antinociception of Glycosylated Dmt1-DALDA Analogues. ACS Medicinal Chemistry Letters, 5(4), 352-357.
Van der Poorten, O., Feher, K., Buysse, K., Feytens, D., Tourwe, D., Martins, J., ... Ballet, S. (2014). LOCALLY CONSTRAINED, AZEPINONE-CONTAINING HUMAN MC4R AGONIST AND HUMAN MC5R ANTAGONIST TETRAPEPTIDE LIGANDS. Journal of Peptide Science, 20(s1), S166-S166. [P088].
De Prins, A., Caveliers, V., Van Eeckhaut, A., Ballet, S., & Smolders, I. J. (2014). Neuromedin U (NMU) and the stress response: Development of new selective CNS active ligands and unveiling the role of NMU in major depression and limbic epilepsy. In PhD Day C4N 2014 (PhD Day C4N 2014).
De Prins, A., Caveliers, V., Van Eeckhaut, A., Ballet, S., & Smolders, I. J. (2014). Neuromedin U (NMU) and the stress response: Development of new selective CNS active ligands and unveiling the role of NMU in major depression and limbic epilepsy.. Poster session presented at PhD day C4N, Jette, Belgium.
Jida, M., & Ballet, S. (2014). One-Pot Isomerization-Cross Metathesis-Reduction (ICMR) Synthesis of Lipophilic Tetrapeptides. ACS Combinatorial Science, 16, 342-351.
Bibian, M., Mangelschots, J., Martin, C., Gardiner, J., Waddington, L., Acevedo, M. M. D., ... Ballet, S. (2014). RATIONAL DESIGN OF INJECTABLE HEXAPEPTIDE HYDROGELATORS FOR CONTROLLED-RELEASE DRUG DELIVERY. Journal of Peptide Science, 20(s1), S208-S208. [P158].
Willemse, T., Smith, D. R. M., Gkotsi, D., Schepens, W., Maes, B. U. W., Ballet, S., & Goss, R. J. M. (2014). SIMPLE AND SCALABLE ACCES TO L-7-HALOTRYPTOPHANS AND OTHER L-HALOTRYPTOPHANS THROUGH AN IMPROVED ONE-POT BIOTRANSFORMATION. Journal of Peptide Science, 20(s1), S143-S144. [P048].
Massa, S., Vikani, N., Vanderhaegen, S., Betti, C., Ballet, S., Caveliers, V., ... Devoogdt, N. (2014). Sortase-mediated site-specific conjugation of nanobodies for use in molecular imaging. In PEGS Congress Lisbon (03/11-07/11/2014)
Lumeng, Y., Cornelis, P., Guillemyn, K., Ballet, S., & Hammerich, O. (2014). Structure revision of N-mercapto-4-formylcarbostyril produced by Pseudomonas fluorescens G308 to 2-(2-hydroxyphenyl)thiazole-4-carbaldehyde [aeruginaldehyde]. Nat Prod Commun, 9, 789-794.
Guillemyn, K., & Ballet, S. (2014). SYNTHESIS AND BIOLOGICAL EVALUATION OF COMPACT, CONFORMATIONALLY CONSTRAINED AND BIFUNCTIONAL OPIOID AGONIST - NEUROKININ-1 ANTAGONIST PEPTIDOMIMETICS. Journal of Peptide Science, 20, 166-167.
Schurgers, B., Brigou, B., Urbanczik-Lipkowska, Z., Tourwe, D., Ballet, S., De Proft, F., ... Verniest, G. (2014). Synthesis of Fused 3-Aminoazepinones via Trapping of a new Class of Cyclic Seven-Membered Allenamides with Furan. Org. lett., 16, 3712-3715.
Smith, D., Willemse, T., Gkotsi, D., Schepens, W., Maes, B., Ballet, S., ... Amos B. Smith, I. (Ed.) (2014). The First One-Pot Synthesis of l-7-Iodotryptophan from 7-Iodoindole and Serine, and an Improved Synthesis of Other l-7-Halotryptophans. Organic Letters, 16(10), 2622-2625.
2013
Lumeng, Y., Ballet, S., Hildebrand, F., Laus, G., Guillemyn, K., Raes, J., ... Cornelis, P. (2013). A combinatorial approach to the structure elucidation of a pyoverdine siderophore produced by a Pseudomonas putida isolate and the use of pyoverdine as a taxonomic marker for typing P. putida subspecies. Biometals, 26, 561-575.
Jida, M., Betti, C., Urbanczyk-Lipkowska, Z., Tourwe, D., & Ballet, S. (2013). Highly Diastereoselective Synthesis of 1-Carbamoy1-4-aminoindoloazepinone Derivatives via the Ugi Reaction. Organic Letters, 15(22), 5866-5869.
Kleckzkowska, P., Lipkowski, A., Tourwe, D., & Ballet, S. (2013). Hybrid Opioid/Non-Opioid Ligands in Pain Research. Current Pharmaceutical Design, 19(42), 7435-7450.
Kleczkowska, P., Bojnik, E., Lesniak, A., Kosson, P., Van den Eynde, I., Ballet, S., ... Lipkowski, A. W. (2013). Identification of Dmt-D-Lys-Phe-Phe-OH as a highly antinociceptive tetrapeptide metabolite of the opioid-neurotensin hybrid peptide PK20. Pharmacological Reports, 65(4), 836-846.
Van Bochaute, P., Novoa, A., Ballet, S., Rognes, S. E., & Angenon, G. (2013). Regulatory mechanisms after short-term and long-term perturbed lysine biosynthesis in the aspartate pathway: the need for isogenes in Arabidopsis thaliana. Physiologia plantarum, 149, 449-460.
Frankiewicz, L., Betti, C., Guillemyn, K., Tourwe, D., Jacquot, Y., & Ballet, S. (2013). Stabilisation of a short α-helical VIP fragment by side chain to side chain cyclisation: a comparison of common cyclisation motifs by circular dichroism. Journal of Peptide Science, 19(7), 423-432.
2012
Buysse, K., Farard, J., Nikolaou, A., Vanderheyden, P., Vauquelin, G., Sejer Pedersen, D., ... Ballet, S. (2012). Amino Triazolo Diazepines (Ata) as Constrained Histidine Mimics. Organic Letters, 13(24), 6468-6471.
Guillemyn, K., Kleczkowska, P., Novoa, A., Vandormael, B., Van Den Eynde, I., Kosson, P., ... Ballet, S. (2012). In vivo antinociception of potent mu opioid agonist tetrapeptide analogues and comparison with a compact opioid agonist - neurokinin 1 receptor antagonist chimera. Molecular Brain, 5(4).
Guillemyn, K., Van Den Eynde, I., Keresztes, A., Varga, E., Lai, J., Porreca, F., ... Ballet, S. (2012). Solid phase synthesis and biological evaluation of novel bifunctional opioid agonist - neurokinin-1 antagonist peptidomimetics. Journal of Peptide Science, 18(s1), 123-124. [P180].
Novoa, A., Van Dorpe, S., Wynendaele, E., Spetea, M., Bracke, N., Stalmans, S., ... Ballet, S. (2012). Variation of the Net Charge, Lipophilicity, and Side Chain Flexibility in Dmt(1)-DALDA: Effect on Opioid Activity and Biodistribution. Journal of Medicinal Chemistry, 55, 9549-9561.
2011
Vandormael, B., De Wachter, R., Martins, J. C., Hendrickx, P. M. S., Keresztes, A., Ballet, S., ... Tourwe, D. (2011). Asymmetric Synthesis and Conformational Analysis by NMR Spectroscopy and MD of Aba- and alpha-MeAba-Containing Dermorphin Analogues. ChemMedChem, 6(11), 2035-2047.
Ballet, S., Feytens, D., Buysse, K., & Tourwe, D. (2011). Design of Novel Neurokinin 1 Receptor Antagonists Based on Conformationally Constrained Aromatic Amino Acids and Discovery of a Potent Chimeric Opioid Agonist-Neurokinin 1 Receptor Antagonist. Journal of Medicinal Chemistry, 54(7), 2467-2467.
Ballet, S., Frankiewicz, L., Guillemin, K., Van Den Eynde, I., & Tourwe, D. (2011). Evaluation of constrained amino acids in the design of neurokinin 1 receptor- and bifunctional opioid - neurokinin 1 receptor ligands. Pharmacological Reports, 63(1), 229-229.
Novoa, A., Tourwe, D., & Ballet, S. (2011). Structural modification and biological evaluation of Dmt1-DALDA analogues. Pharmacological Reports, 63(1), 231-231.
De Wachter, R., De Graaf, C., Keresztes, A., Vandormael, B., Ballet, S., Tóth, G., ... Tourwe, D. (2011). Synthesis, Biological Evaluation, and Automated Docking of Constrained Analogues of the Opioid Peptide H-Dmt-D-Ala-Phe-Gly-NH2 Using the 4- or 5-Methyl Substituted 4-Amino-1,2,4,5-tetrahydro-2-benzazepin-3-one Scaffold. Journal of Medicinal Chemistry, 54(19), 6538-6547.
2010
Ballet, S., Marczak, . E. D., Feytens, D., & Tourwe, D. (2010). Novel multiple opioid ligands based on 4-aminobenzazepinone (Aba), azepinoindole (Aia) and tetrahydroisoquinoline (Tic) scaffolds. Bioorganic & Medicinal Chemistry Letters, 20(5), 1610-1613.
Kleczkowska, P., Kosson, P., Ballet, S., Van Den Eynde, I., Tsuda, Y., Tourwe, D., & Lipkowski, A. (2010). PK20, a new opioid-neurotensin hybrid peptide that exhibits central and peripheral antinociceptive effects. Molecular Pain, 6, [86].
2009
Ballet, S., Feytens, D., De Wachter, R., De Vlaeminck, M., Marczak, E. D., Salvadori, S., ... Balboni, G. (2009). Conformationally constrained opioid ligands: The Dmt-Aba and Dmt-Aia versus Dmt-Tic scaffold. Bioorganic & Medicinal Chemistry Letters, 19(2), 433-437. DOI: 10.1016/j.bmcl.2008.11.051
De Wachter, R., Brans, L., Ballet, S., Van Den Eynde, I., Feytens, D., Keresztes, A., ... Tourwe, D. (2009). Influence of ring substitution on the conformation and beta-turn mimicry of 4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-one peptide mimetics. Tetrahedron, 65, 2266-2278.
Ebert, M-O., Gardiner, J., Ballet, S., Abell, A. D., & Seebach, D. (2009). Synthesis and High-Resolution NMR Structure of a beta(3)-Octapeptide with and without a Tether Introduced by Olefin Metathesis. Helvetica Chimica Acta, 92(12), 2643-2658.
2008
Ballet, S., Misicka, A., & Tourwe, D. (2008). Blood-Brain barrier penetration by two dermorphin tetrapeptide analogues: Role of lipophilicity vs structural flexibility. Journal of Medicinal Chemistry, 51(8), 2571-2574.
Vernall, A. J., Ballet, S., & Abell, A. D. (2008). Cross-metathesis and ring-closing metathesis reactions of amino acid-based substrates. Tetrahedron, 64(18), 3980-3997. DOI: 10.1016/j.tet.2008.02.043
Tömböly, C., Ballet, S., Feytens, D., Köver, K. E., Attila, B., Lovas, S., ... Tourwe, D. (2008). Endomorphin-2 with a beta turn backbone constraint retains the potent mu-opioid receptor agonist properties. Journal of Medicinal Chemistry, 51(1), 173-177.
Ballet, S., Pietsch, M., & Abell, A. D. (2008). Multiple Ligands in Opioid Research. Protein and Peptide Letters, 15(7), 668-682.
2007
Tóth, G., Ioja, E., Tömböly, C., Ballet, S., Tourwe, D., Peter, A., ... Borsodi, A. (2007). beta-Methyl substitution of cyclohexylalanine in Dmt-Tic-Cha-Phe peptides results in highly potent delta opioid antagonists. J. Med. Chem., 50, 328-333.
Ballet, S., De Wachter, R., Van Rompaey, K., Tömböly, C., Feytens, D., Tóth, G., ... Tourwe, D. (2007). Bradykinin analogs containing the 4-amino-2-benzazepin-3-one scaffold at the C-terminus. Journal of Peptide Science, 13, 164-170.
Ballet, S., De Wachter, R., Maes, V., & Tourwe, D. (2007). Derivatization of 1-phenyl substituted 4-amino-2benzazepin-3-ones : evaluation of Pd-catalyzed coupling reactions. Tetrahedron, 63(18), 3718-3727.
Ballet, S., Van Rompaey, K., & Tourwe, D. (2007). High-performance liquid chromatographic separation of stereoisomers of N-phthaloyl-protected amino acids and dipeptidomimetics. Journal of Separation Science, 30(12), 1881-1887.
Ballet, S., & Tourwe, D. (2007). Novel Selective human melanocortin-3 receptor ligands : Use of the 4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-one (Aba) scaffold. Bioorganic & Medicinal Chemistry Letters, 17(9), 2492-2498.
2006
Ballet, S., Salvadori, S., Trapella, C., Bryant, S. D., Jinsmaa, J., Lazarus, L. H., ... Balboni, G. (2006). New 2',6'-dimethyl-L-Tyrosine (Dmt) Opioid Peptidomimetics Based on the Aba-Gly Scaffold. Development of Unique µ-Opioid Receptor Ligands. J Med Chem, 49, 3990-3993.
Van Rompaey, K., Ballet, S., Tömböly, C., De Wachter, R., Vanommeslaeghe, K., Biesemans, M., ... Tourwe, D. (2006). Synthesis and evaluation of the beta-turn properties of 4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-ones and of their spirocyclic derivative. Eur. J. Org. Chem., 2899-2911.
2005
Ballet, S., Frycia, A., Piron, J., Chung, N., Schiller, P., Kosson, P., ... Tourwe, D. (2005). Synthesis and biological evaluation of constrained analogues of the opioid peptide H-Tyr-D-Ala-Phe-Gly-NH2 using 4-amino-2-benzazepin-3-one scaffold. J. Pept. Res., 66, 222-230.
Ballet, S., Urbanczik-Lipkowska, Z., & Tourwe, D. (2005). Synthesis of substituted 4-amino-2-benzezepin-3-ones via N-acyliminium ion cycliations. Synlett, 18, 2791-2795.
Van Den Eynde, I., Van Rompaey, K., Willem, R., Ballet, S., De Wachter, R., Vanommeslaeghe, K., ... Tourwe, D. (2005). Synthesis of 4-amino-1,2,4,5-tetrahydro-2-benzazepine-3-ones and study of their beta-turn inducing properties. Biopolymers, 80, 569-569.
Biesemans, M., Tourwe, D., Willem, R., De Wachter, R., Van Rompaey, K., Vanommeslaeghe, K., ... Tömböly, C. (2005). The 2-Benzazepin-3-one Structure as a beta-turn Mimic: Synthesis and Conformational Analysis. In Peptides 2004: Proceedings of the 3rd International and 28th European Peptide Symposium, M. Flegel, M. Fridkin, C. Gilon and J. Slaninova (Editors), Kenes International (Genève, Zwitserland) 2005, pp. 698–699 Peptides 2004: Proceedings of the 3rd International and 28th European Peptide Symposium, M. Flegel, M. Fridkin, C. Gilon and J. Slaninova (Editors), Kenes International (Genève, Zwitserland) 2005, pp. 698 699.