CMIM PhD Theses

2021

Cancer-induced local and systemic reprogramming of myeloid cells and its impact on disease progression
KISS Máté
Promotors: VAN GINDERACHTER Jo, LAOUI Damya

Multi-omic analysis of glioblastoma-associated myeloid cells across species and disease stages
POMBO ANTUNES Ana Rita
Promotors: VAN GINDERACHTER Jo, MOVAHEDI Kiavash

2020

Effect of different characteristics of radiometal labelled Nanobodies on the kidney retention
CRAUWELS Maxine
Promotors: MUYLDERMANS Serge, VAN GINDERACHTER Jo, XAVIER Catarina, DEVOOGDT Nick

2019

Nanobody-mediated targeting of tumor-associated macrophages for cancer therapy
BOLLI Evangelia
Promotors: VAN GINDERACHTER Jo, MOVAHEDI Kiavash

2018

Intrabody targeting hypoxia inducible factor-1α mediates transcriptional downregulation of target genes related to solid tumors
HU Yaozhong
Promotor: MUYLDERMANS Serge

Glycolytic enzymes from Trypanosoma as targets for parasite detection and control
PINTO TORRES Joar
Promotor: MAGEZ Stefan

2017

Development of a Nanobody-based rapid antigen test to detect active Trypanosoma infections in livestock
GOOSSENS Julie
Promotor: MAGEZ Stefan

Functional role of tumour-associated dendritic cells and liver Kupffer cells during solid tumour progression and liver metastasis, respectively.
KEIRSSE Jiri
Promotors: VAN GINDERACHTER Jo, DE BAETSELIER Patrick

2016

Nanobodies as Tools to Monitor Myeloid Cells and Modulate Inflammatory Responses during Disease States.
SPARKES Amanda
Promotors: DE BAETSELIER Patrick, RAES Geert, STIJLEMANS Benoît

Targeting Plasmodium falciparum PfSUB-2 and VAR2CSA proteins to gain new insights in malaria-host interaction
FLOREA Raluca
Promotor: MAGEZ Stefan

Exploring the immunopathology during Leishmania donovani and Leishmania major infections
KAUFFMANN Florence
Promotors: MAGEZ Stefan, DE TREZ Carl

Nanobody-based Immunoassay for Trypanosoma congolense Targeting Glycosomal Fructose-1,6-Bisphosphate Aldolase
ODONGO Steven
Promotors: MAGEZ Stefan

Site-specific labeling of nanobody-based radioimmunotracers on the road to pancreatic beta cell targeting.
MASSA Sam
Promotors: DEVOOGDT Nick, XAVIER Catarina, MUYLDERMANS Serge

2015

Characterization and regulation of distinct macrophage subsets during tissue injury and tumor growth.
VAN OVERMEIRE Eva
Promotors: DE BAETSELIER PATRICK, VAN GINDERACHTER JO

Unravelling the role of Neuraminidase in the immunopathology of T. vivax infections.
HAYNES Carole
Promotors: MAGEZ STEFAN, CALLEWAERT NICO

Assessing the role of IFN and CD8 T-cells in trypanosomiasis associated anemia
CNOPS Jennifer
Promotor: MAGEZ STEFAN

2014

Regulation of the molecular and functional heterogeneity of tumor-associated macrophages and dendritic cells.
LAOUI Damya
Promotors: DE BAETSELIER PATRICK, VAN GINDERACHTER Jo

Nanobody-based targeting of tissue macrophages for inflammation monitoring during experimental arthritis and hepatitis
ZHENG Fang
Promotors: DE BAETSELIER PATRICK, MUYLDERMANS SERGE

Impact of experimental chronic Trypanosoma congolense infection on the host's B-cell homeostasis and generation of nanobody for parasite detection.
OBISHAKIN Emmanuel tumininu
Promotor: MAGEZ Stefan

Non-invasive in vivo imaging of atherosclerotic plaques using camelid single-domain antibody-fragments as molecular tracers.
DE VOS Jens
Promotors: MUYLDERMANS SERGE, DEVOOGDT NICK, LAHOUTTE Tony

2013

Development of nanobody-based chromatin immunoprecipitation (Nb-ChIP) for genome-wide study of a transcriptional regulator.
NGUYEN DUC Trong
Promotors: MUYLDERMANS SERGE, CHARLIER DANIEL, PEETERS Eveline

Gene expression profiling of monocytes in the HIV/tuberculosis-associated immune reconstitution inflammatory syndrome.
TRAN THI THANH Huyen
Promotors: DE BAETSELIER PATRICK, Kestens Luc

Trypanosoma vivax : Nanobody(R)targeting and contribution of tumor necrosis factor to the control of experimental trypanosomiasis.
LA GRECA SAINT ESTEVEN Florencia
Promotors: MAGEZ Stefan, GARCIA-SALCEDO José A.

Characterization of novel angiotensin IV analogues as tools to elucidate the regulation of the insulin-regulated aminopeptidase in macrophages
NIKOLAOU Alexandros
Promotors: VAN GINDERACHTER Jo, VANDERHEYDEN PATRICK

Mechanims of myeloid-derived suppressor cell-mediated immune regulation in cancer
SCHOUPPE Elio
Promotors: DE BAETSELIER PATRICK, VAN GINDERACHTER Jo

Characterization of different myeloid cell subsets and their role in liver pathogenicity induced by African trypanosome infection
MORIAS Yannick
Promotors: DE BAETSELIER PATRICK, BESCHIN Alain

2012

Trypanosomiasis-associated modulation of B cell lymphopoiesis and immune function.
BOCKSTAL Viki
Promotor: MAGEZ Stefan

2011

Involvement of galectin-3 in inflammation-associated immunopathology elicited during African trypanosomiasis
VANKRUNKELSVEN ANN
Promotors: DE BAETSELIER PATRICK, STIJLEMANS BENOIT

Regulation and function of alternatively activated macrophage markers; a focus on E-cadherin.
VAN DEN BOSSCHE Jan
Promotors: DE BAETSELIER PATRICK, VAN GINDERACHTER Jo

2010

The role of interleukin-10 and monocytic cells in liver pathogenicity during African trypanosome infection.
BOSSCHAERTS TOM
Promotors: BESCHIN ALAIN, DE BAETSELIER PATRICK

Nanobodies as molecular probes for targeting of dendritic cells
DE GROEVE Kurt
Promotors: DE BAETSELIER PATRICK, RAES GEERT

Immunoglobulin genes and generation of antibdoy repertoires in camelids
DESCHACHT NICK
Promotor: MUYLDERMANS SERGE

Molecular and functional heterogeneity of myeloid cells in cancer.
MOVAHEDI Kiavash
Promotors: DE BAETSELIER PATRICK, VAN GINDERACHTER Jo

2009

Characterization of Epidermal Growth Factor (EGF) receptor targeting Nanobodies and ABIN for the treatment of EGF receptor-dependent tumours
HUANG Lieven
Promotors: DE BAETSELIER PATRICK, BEYAERT Rudy

Humanization of Nanobodies and identification of Nanobodies for Alzheimer's disease immunotherapy.
VINCKE CECILE
Promotor: MUYLDERMANS SERGE

The invariant surface glycoprotein ISG75 : a target for vaccination and diagnosis of trypanosomiasis
TRAN THAO
Promotors: MAGEZ Stefan, Büscher P.

Transcriptome analysis of monocyte-HIV interactions
VAN DEN BERGH Rafael
Promotors: DE BAETSELIER PATRICK, VANHAM Guido

2008

IL-10 and regulatory T cells limit the pathogenicity of African trypanosome infection
GUILLIAMS Martin
Promotors: BESCHIN ALAIN, DE BAETSELIER PATRICK

2006

Study of the inflammation-associated anemia in African trypanosomiasis and development of anti-disease and drug-targeting strategies
STIJLEMANS BENOIT
Promotors: DE BAETSELIER PATRICK, MAGEZ Stefan

Functional characterization of Glossina morsitans morsitans saliva in the context of African trypanosome transmission
CALJON Guy
Promotors: DE BAETSELIER PATRICK, MAGEZ Stefan

Development of alternative strategies for control of human and livestock trypanosomiasis
BARAL Toya
Promotors: DE BAETSELIER PATRICK, MAGEZ Stefan

Study of the inflammation-associated anemia in African trypanosomiasis and development of anti-disease and drug-targetting strategies
STIJLEMANS BENOIT
Promotors: DE BAETSELIER PATRICK, MAGEZ Stefan

2005

The immune modulatory activities of Mycobacterium tuberculosis-derived mycolic acids
KORF Johanna
Promotors: DE BAETSELIER PATRICK, GROOTEN Johan

Identification and optimization of camel single-domain antibodies against diagnostically relevant antigens
SAERENS Dirk
Promotor: MUYLDERMANS SERGE

2004

Molecular recognition and maturation of camelid heavy chain antibodies
DE GENST ERWIN
Promotors: MUYLDERMANS SERGE, WYNS LODE

Nanobodies : single-domain antibody fragments as imaging agents and modular building blocks for therapeutics
CORTEZ RETAMOZO Virna
Promotors: DE BAETSELIER PATRICK, REVETS HILDE

Anti hapten heavy chain antibodies from camelidae
SERRAO Maria-Teresa
Promotors: MUYLDERMANS SERGE, WYNS LODE

Signal transduction mediators of P190 BCR/ABL induced leukemia
HEMMERYCKX Bianca
Promotor: DE BAETSELIER PATRICK, REVETS HILDE

Investigating the role of type II cytokines and alternatively activated macrophages in tolerance to African trypanosomosis
NOEL Wim
Promotor: DE BAETSELIER PATRICK

Mechanisms uderlying the cancer-promoting activities of endogenous TNFalpha
DEVOOGDT NICK
Promotors: DE BAETSELIER PATRICK, HASSANZADEH GHASSABEH Gholamreza

Tumor-induced immune suppression : a study of the murine BW lymphoma model
LIU Yuanqing
Promotor: DE BAETSELIER PATRICK

2003

African trypanosomiasis : molecular and biological characterization of a novel trypanosome-immunomodulaory factor
GOMEZ Julio
Promotor: DE BAETSELIER PATRICK

2002

Selection and genetic engineering of camel single-domain antibodies wirth improved properties for biotechnological applications.
CONRATH Katja
Promotor: MUYLDERMANS SERGE

The camel (Camelus dromedaries) immunoglobulin light chains
LEGSSYER Ilham
Promotor: MUYLDERMANS SERGE

The tissue-infiltrative behavior of lymphoid cells : the role of the cytoskeleton and of the small GTP-binding protien Rap 1.
VAN DER TAELEN IMME
Promotors: DE BAETSELIER PATRICK, VERSCHUEREN Hendrik

Innate and adaptive immunity against a murine T cell lymphoma
VAN GINDERACHTER Jo
Promotor: DE BAETSELIER PATRICK

2001

Genomic organisation and dynamics of the g p63 genes in Leishmania (Viannia) braziliensis and Leishmania (Viannia) peruviana : functional and diagnostic implications.
VICTOIRE Kathleen
Promotors: DE BAETSELIER PATRICK, DUJARDIN Jean-Claude

Contribution to the study of the host-parasie relationship in Toxoplasma gondii infection : characterisation of Fc receptor activity on tachyzoites and use of DNA vaccination for the induction of protective immunity in a murine model.
VERCAMMEN Martine
Promotor: DE BAETSELIER PATRICK

Probing the immunotechnological properties of a Pseudomonal lipoprotein
JONGERT Erik
Promotors: DE BAETSELIER PATRICK, REVETS HILDE

Generation of heavy-chain antibodies in camelids.
NYUGEN Khong Viet
Promotor: MUYLDERMANS SERGE

L-OprI-based strategies to vaccination against Leishmaniasis.
BREDAN Amin
Promotors: DE BAETSELIER PATRICK, REVETS HILDE

Contribution to the Study of the Host-Parasite Relationship in Toxoplasma Gondii Infection: Characterization of Fc Receptor Activity on Tachyzoites and Use of DNA Vaccination for the Induction of Protective Immunity in a Murine Model.
VERCAMMEN MARTINE
Promotor: DE BAETSELIER PATRICK

2000

Immunity elicited by OprI-based recombinant Leishmania antigens.
COTE-SIERRA Javier
Promotor: DE BAETSELIER PATRICK

Host-parasite interactions during murine African trypanosomosis.
NAMANGALA Boniface
Promotors: BESCHIN ALAIN, DE BAETSELIER PATRICK

Resistance of African Trypanosomes to normal human serum.
XONG Hoang Van
Promotor: DE BAETSELIER PATRICK

1999

Host-tumor interactions in a murine T cell lymphoma model : from analysis to immunotherapeutic intervention.
RAES Geert
Promotor: DE BAETSELIER PATRICK

Binding of the globular domain of linker histone H1 and H5 to nucleosomes and branched DNA.
ZHOU Ying Bing
Promotor: MUYLDERMANS SERGE

Llama Antibodies and Engineering of Single-domain Antibody Fragments
Vu Khoa Bang
Promotors: MUYLDERMANS SERGE, WYNS LODE

1998

Molecular analysis of the karyotype diversity between two clonal lines of Leishmania mexicana M379, the Garnham line (ITMAP 2167) and the Evans line (ITMAP 2043)
HANH Nguyen Thi Hong
Promotor: DE BAETSELIER PATRICK

Intrabody-mediated gene modulation in Drosophila.
HASSANZADEH GHASSABEH Gholamreza
Promotors: DE BAETSELIER PATRICK, DAMBLY-CHAUDIÈRE C.

1997

Immunosuppression during experimental malaria : Interactions between Plasmodium c. chabaudi macrophages and T cells
SCORZA Tatiana
Promotor: DE BAETSELIER PATRICK

Versatile effects of gene therapy on the immune resistance of T lymphoma cells
GELDHOF Anja
Promotor: DE BAETSELIER PATRICK

Immunopathogenesis of experimental African trypanosomiasis. Interaction between Trypanosoma brucei brucei, macrophages and Tumor necrosis factor
MAGEZ Stefan
Promotor: DE BAETSELIER PATRICK

The immune response of trypanosusceptible and trypanotolerant cattle to African trypanosomiasis.
TAYLOR Katherine
Promotor: DE BAETSELIER PATRICK

Neutralizing antibody patterns in sera of individuals infected with human immunodeficiency virus (HIV) type 1, HIV-2 and simian imunodeficiency virus (SIVcpz) to their homologous and heterologous isolates.
NYAMBI NYAMBI Philippe
Promotors: DE BAETSELIER PATRICK, VAN DER GROEN Patrick

Genomic rearrangements associated with the expression of serum resistant variants in Trypanosoma brucei rhodesiense : ETAR-1
CHIMFWEMBE Chibeka Evelyn
Promotor: DE BAETSELIER PATRICK

1996

A study on tumor growth and progression : mutual and adaptive responses within the tumor-host ecocystem.
TORREELE Els
Promotor: DE BAETSELIER PATRICK

Organ specific metastasis of T lymphomas. A study on selective interactions with the organ micro-environment.
SCHMIDT Corina
Promotor: DE BAETSELIER PATRICK

Genetic evidence for additional phylogenetic subtypes within the human immunodeficiency virus type 1 lineage.
VANDEN HAESEVELDE Marleen
Promotors: DE BAETSELIER PATRICK, SAMAN Erik

Generation and characterization of phage-displayed camel single domain antibodies.
GHAHROUDI Mehdi Arbabi
Promotor: MUYLDERMANS SERGE

1994

Studie van gemodifieerde eiwitexpressie als gevolg van schuimcel vorming in een human makrofaag model
UNION Ann
Promotor: DE BAETSELIER PATRICK

1993

Functional Dissection of Tumor Necrosis Factor
LUCAS Rudolf
Promotor: DE BAETSELIER PATRICK

Mechanisms underlying T.b. brucei-associated immunosuppression
DARJI Ayub
Promotor: DE BAETSELIER PATRICK

1992

Scrutiny of subunit immunogens.
SCHEERLINCK Jean-Pierre Y.
Promotor: DE BAETSELIER PATRICK

Role of major histocompatibility Class I antigens in tumorigenicity and metastasis of T lymphoma cells.
VANDENDRIESSCHE Thierry
Promotor: DE BAETSELIER PATRICK

1988

Dual role of macrophages in the potential of Trypanosoma brucei to block interleukin 2 production and interleukin 2 receptor expression.
SILEGHEM Maarten
Promotor: DE BAETSELIER PATRICK

Immunobiology of macrophage-tumor interactions.
REMELS Linda
Promotor: DE BAETSELIER PATRICK