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Selected publication list
Articles
- Hendrickx M, Van XH, Leyns L. (2009)
Anterior-posterior patterning of neural differentiated embryonic stem cells by canonical Wnts, Fgfs, Bmp4 and their respective antagonists.
Dev Growth Differ. 2009 Aug 23. [Epub ahead of print] - Pubmed
- Willems E. and L. Leyns “Patterning of mouse embryonic stem cell-derived pan-mesoderm by Activin A/Nodal and Bmp4 signaling requires fibroblast growth factor activity”
Differentiation 2008, 76:745-59 - Pubmed
- D. Piette, M. Hendrickx, E. Willems, C. R Kemp and L. Leyns (2008) “ An optimized procedure for whole-mount in situ hybridization on mouse embryos and embryoid bodies”
Nature Protocols 7: 1194-1201 - Pubmed
- Hendrickx M. and L. Leyns “Non conventional Frizzled ligands and Wnt receptors”
Development, Growth & Differentiation, 2008, 50:229-243 - Pubmed
- Willems E., L. Leyns and J.Vandesompele. 2008 “Standardization of real-time PCR gene expression data from independent biological replicates”
Analytical Biochemistry 379:127-29 - Pubmed
- M. Thomas-Chollier, L. Leyns and V. Ledent. “HoxPred: automated classification of Hox proteins using combinations of generalised profiles”
BMC Bioinformatics 2007, 8:247 - Pubmed
- C. Kemp, E. Willems, D. Wawrzak, M. Hendrickx, T. Agbor Agbor and L. Leyns “Expression of Frizzleds during early mouse development and interactions with canonical Wnt signaling”
Developmental Dynamics 2007, 236:2011-9 - Pubmed
- D. Wawrzak, M. Métioui, E. Willems, M. Hendrickx, E. de Genst and L. Leyns “SFRP1, sFRP2, sFRP4 and Frzb bind Wnt3a in the nanomolar range while only sFRP1 and sFRP2 antagonize Wnt3a activity”
Biochem Biophys Res Commun. 2007 Jun 15;357(4):1119-23 - Pubmed
- Kemp C., M. Hendrickx, E. Willems, D. Wawrzak, M. Métioui and L. Leyns 2007 “The Roles of Wnt Signaling in Early Mouse Development and Embryonic Stem Cells”
Functional Development and Embryology 1(1): 1-13
- Willems E., Mateizel I., Kemp C., Caufman G., Sermon K. and L. Leyns “Identification of suitable reference genes in mouse and human embryonic stem cell differentiation and in mouse embryonic development”.
International Journal of Developmental Biology 50(7):627-35, 2006 - Pubmed
- J. Verheyde, L. de Saint-Georges, L. Leyns and M.A. Benotmane “The role of Trp53 in the transcriptional response to ionizing radiation in the developing brain”
DNA research 13: 65-75, 2006 - Pubmed
- C. E. Pierreux, A. V. Poll, C. R. Kemp, F. Clotman,
M. A. Maestro, S. Cordi, J. Ferrer, L. Leyns, G.
G. Rousseau and
F. P. Lemaigre “The transcription factor HNF-6 controls
the development of pancreatic ducts and regulates a cystic disease
gene network”
Gastroenterology. 2006 Feb;130(2):532-41. - Pubmed
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Mannaert A., Roelants K., Bossuyt F. and Leyns
L. “A
PCR survey for posterior Hox genes in amphibians”.
Molecular Phylogenetics and Evolution 38:449-458, 2006 - Pubmed
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Mfopou Kunjom J., Willems E., Leyns L., Bouwens
L. “mRNA
expression of regulatory genes for pancreas developmentduring
murine embryonic stem cell differentiation”.
Int. J. Dev. Biol. 49: 915-922, 2005 - PubMed
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C. Kemp, E. Willems, S. Abdo, L. Lambiv and
L. Leyns. “Expression
of all Wnt genes and their secreted antagonists during
mouse blastocyst and postimplantation development. “
Developmental Dynamics 233: 1064-1075, 2005 - PubMed
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D.Duprez, L.Leyns, M-A.Bonnin, F.Lapointe, H.Etchevers,
E.M. De Robertis and N. Le Douarin. “Expression
of Frzb-1 during chick development”
Mechanism of Development, 89: pp179-183, 1999. - PubMed
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U.Borello,
M.Coletta, S.Tajbakhsh, L.Leyns, E.M. De Robertis, M.Buckingham
and G.Cossu. “ Trans-placental delivery of
the Wnt antagonist Frzb1 inhibits development of caudal
paraxial mesoderm and skeletal myogenesis in mouse embryos.
Development 126: 4247-4255, 1999. - PubMed
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S.Piccolo, E.Agius,
L.Leyns, S.Bhattacharyya, H.Grunz, T.Bouwmeester and
E.M.De Robertis. “The head inducer Cerberus
is a multifunctional antagonist of Nodal, BMP and
Wnt signals.”
Nature, 397: 707-710, 1999. - PubMed
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J.A.Belo, L.Leyns, G.Yamada
and E.M.De Robertis. “The
prechordal midline of the chondrocranium is defective
in Goosecoid-1 mouse mutants.”
Mechanism of Development, 72:15-25, 1998 (+issue cover).
- PubMed
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J.A.Belo, T.Bouwmeester, L.Leyns, N.Kertesz,
M.Gallo, M.Folleti
and E.M.De Robertis. “Cerberus-like is a secreted
factor with neuralizing activity expressed in the anterior
primitive
endoderm of the mouse gastrula.”
Mechanism of Development, 68: 45-58, 1997 (+ issue cover).
- PubMed
-
Leyns
L., T.Bouwmeester, S-H.Kim, S.Piccolo and E.M. De Robertis. “ Frzb-1
is a secreted antagonist of Wnt signaling expressed in
Spemann organizer.”
Cell, 88: 747-756, 1997. - PubMed
-
Leyns L, J-L.Gomez-Skarmeta
and C.Dambly-Chaudière. “iroquois;
a prepattern gene that controls the formation of bristles
on the thorax of Drosophila.”
Mechanisms of Development 59:63-72, 1996. - PubMed
Review articles.
-
L.Leyns, D.Piette and M. Thomas-Chollier “Evo-Devo:
paleontologie zonder fossielen?” (2005), pp125-146
in “Evolutie
vandaag” ed. I.Tallon et al – VUBpress.
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L.Leyns and C.Kemp “Formation and function of the mouse
organizer” (2004) Chap 24, pp409-422 in “The vertebrate
organizer” ed. H.Gruntz – Springer-Verlag.
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Kemp C.R., D. Wawrzak, E. Willems, M. Metioui,
M. Hendrickx and L. Leyns. “Embryonic Stem cells: from research to therapy” (2004)
Human Ecology (Special Issue) 12:49-57
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T.Bouwmeester and L.Leyns. “Vertebrate
head induction by anterior primitive endoderm.”
Bioessays 19 855-863, 1997.
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E.M. De Robertis, S.Kim, L.Leyns,
S.Piccolo, D.Bachiller, E.Agius, J.A.Belo, A.Yamamoto,
A.Hainski-Brousseau, B.Brizuela,
O.Wesseley,
B.Lu and T.Bouwmeester. “Patterning by genes expressed
in Spemann’s organizer” - Cold Spring Harbor
symposia on quantitative biology ; v.LXII, 169-175
(1997).
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