Constraining the Side Chain of C‑Terminal Amino Acids in Apelin-13 Greatly Increases Affinity, Modulates Signaling, and Improves the Pharmacokinetic Profile
Trân, K.; Van Den Hauwe, R.; Sainsily, X.; Couvineau, P.; Côté, J.; Simard, L.; Echevarria, M.; Murza, A.; Serre, A.; Théroux, L.; Saibi, S.; Haroune, L.; Longpré, J-M.; Lesur, O.; Auger-Messier, M.; Spino, C.; Bouvier, M.; Sarret, P.; Ballet, S.; Marsault, E.; J. Med. Chem., ASAP...
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Structure–Activity Relationship (SAR) Study of Spautin-1 to Entail the Discovery of Novel NEK4 Inhibitors
Elsocht, M.; Giron, P.; Maes, L.; Wim Versées. W.; Gutierrez, G.J.; De Grève, J.; Ballet S.; Int. J. Mol. Sci. 2021, 22(2), 635
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Enantioselective Dihalogenation of Alkenes
Bock, J.; Guria, S.; Wedek, V.; Hennecke, U., Chem. Eur. J. 2021, 27, 4517-4530.
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Structure-Based Design of Melanocortin 4 Receptor Ligands Based on the SHU-9119-hMC4R Cocrystal Structure
Martin, C.; Gimenez, L. E.; Williams, S. Y.; Jing, Y.; Wu, Y.; Hollanders, C.; Van der Poorten, O.; Gonzalez, S.; Van holsbeeck, K.; Previti, S.; Lamouroux, A.; Zhao, S.; Tourwé, D.; Stevens R.C.; Cone R.D.; Ballet, S., J. Med. Chem. 2021, 64, 1, 357–369
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Anti-human PD-L1 Nanobody for Immuno-PET Imaging: Validation of a Conjugation Strategy for Clinical Translation
Bridoux, J.; Broos, K.; Lecocq, Q.; Debie, P.; Martin, C.; Ballet, S.; Raes, G.; Neyt, S.; Vanhove, C.; Breckpot, K.; Devoogdt, N.; Caveliers, V.; Keyaerts, M.; Xavier, C.; Biomolecules, 2020, 10(10), 1388.
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Optimized Opioid-Neurotensin Multitarget Peptides: From Design to Structure–Activity Relationship Studies
Gonzalez, S.; Dumitrascuta, M.; Eiselt, E.; Louis, S.; Kunze, L.; Blasiol, A.; Vivancos, M.; Previti,S.; Dewolf, E.; Martin, C.; Tourwé, D.; Cavelier, F.; Gendron, L.; Sarret, P.; Spetea, M.; Ballet, S.; J. Med. Chem. 2020, 63, 21, 12929–12941
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Our work on Opioid-Neurotensin Multitarget Peptides has been featured
We are proud to share that our work on "Optimized Opioid-Neurotensin Multitarget Peptides: From Design to Structure–Activity Relationship Studies" has been featured on the cover of the journal of medicinal chemistry. For the full read, check the publisher's page
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Peptide-based targeting of connexins and pannexins for therapeutic purposes
Caufriez, A;, Böck, D.; Martin, C.; Ballet, S.; Vinken, M.; Expert Opinion on Drug Discovery, 2020, 15(10), 1213-1222.
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Insightful Backbone Modifications Preventing Proteolytic Degradation of Neurotensin Analogs Improve NTS1-Induced Protective Hypothermia
Previti, S.; Vivancos, M.; Rémond, E.; Beaulieu, S.; Longpré, J. M.; Ballet, S.; Sarret, P.; Cavelier, F.; Frontiers in Chemistry, 2020, 8, 406
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Mechanistic Understanding of Peptide Analogues, DALDA, [Dmt1]DALDA, and KGOP01, Binding to the Mu Opioid Receptor
Dumitrascuta, M.; Bermudez, M.; Ballet, S., Wolber, G.; Spetea, M. Molecules, 2020, 25(9), 2087.
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Effects of neuromedin U-8 on stress responsiveness and hypothalamus-pituitary-adrenal axis activity in male C57BL/6J mice.
De Prins A.; Allaoui W.; Medrano M.; Van Eeckhaut A.; Ballet S.; Smolders I.; De Bundel D. Hormones and Behavior, 2020, 121, 104666.
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The Neurokinins: Peptidomimetic Ligand Design and Therapeutic Applications
Gadais, C.; Ballet, S. Current medicinal chemistry, 2020, 27(9), 1515-1561.
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