Novel multiple opioid ligands based on 4-aminobenzazepinone (Aba), azepinoindole (Aia) and tetrahydroisoquinoline (Tic) scaffolds.
Ballet, S.; Marczak, E. D.; Feytens, D.; Salvadori, S.; Sasaki, Y.; Abell, A. D.; Lazarus, L. H.; Balboni, G.; Tourwé, D., Bioorg. Med. Chem. Lett. 2010, 20, 1610-1613.
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Crystal Structure of the T(6-4)C Lesion in Complex with a (6-4) DNA Photolyase and Repair of UV-Induced (6-4) and Dewar Photolesions
A. F. Glas, S. Schneider, M. J. Maul, U. Hennecke, T. Carell, Chem. Eur. J. 2009, 15, 10387-10396.
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Synthesis and High-Resolution NMR Structure of a beta(3)-Octapeptide with and without a Tether Introduced by Olefin Metathesis.
Ebert, M. O.; Gardiner, J.; Ballet, S.; Abell, A. D.; Seebach, D., Helv. Chim. Acta 2009, 92, 2643-2658.
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N to C Aryl Migration in Lithiated Carbamates: alpha-Arylation of Benzylic Alcohols
J. Clayden, W. Farnaby, D. M. Grainger, U. Hennecke, M. Mancinelli, D. J. Tetlow, I. H. Hillier, M. A. Vincent, J. Am. Chem. Soc. 2009, 131, 3410-3411.
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α-Arylation of Cyclic Amines by Aryl Transfer in Lithiated Ureas
R. Bach, J. Clayden, U. Hennecke, Synlett 2009, 421-424.
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Conformationally constrained opioid ligands: The Dmt-Aba and Dmt-Aia versus Dmt-Tic scaffold.
Ballet, S.; Feytens, D.; De Wachter, R.; De Vlaeminck, M.; Marczak, E. D.; Salvadori, S.; de Graaf, C.; Rognan, D.; Negri, L.; Lattanzi, R.; Lazarus, L. H.; Tourwe, D.; Balboni, G., Bioorg. Med. Chem. Lett. 2009, 19, 433-437.
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Influence of ring substitution on the conformation and beta-turn mimicry of 4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-one peptide mimetics.
De Wachter, R.; Brans, L.; Ballet, S.; Van den Eynde, I.; Feytens, D.; Keresztes, A.; Toth, G.; Urbanczyk-Lipkowska, Z.; Tourwe, D., Tetrahedron 2009, 65, 2266-2278.
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Recognition and Repair of UV Lesions in Loop Structures of Duplex DNA by DASH-Type Cryptochrome
R. Pokorny, T. Klar, U. Hennecke, T. Carell, A. Batschauer, L.-O. Essen, Proc. Natl. Acad. Sci. U. S. A. 2008, 105, 21023-21027.
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α-Pyridinylation of Chiral Amines via Urea Coupling, Lithiation and Rearrangement: Synthesis of α-Arylated Nicotine Analogues
J. Clayden, U. Hennecke, Org. Lett. 2008, 10, 3567-3570.
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Cross-metathesis and ring-closing metathesis reactions of amino acid-based substrates.
Vernall, A. J.; Ballet, S.; Abell, A. D., Tetrahedron 2008, 64, 3980-3997.
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Blood-Brain barrier penetration by two dermorphin tetrapeptide analogues: Role of lipophilicity vs structural flexibility.
Ballet, S.; Misicka, A.; Kosson, P.; Lemieux, C.; Chung, N. N.; Schiller, P. W.; Lipkowski, A. W.; Tourwe, D., J. Med. Chem. 2008, 51, 2571-2574.
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Endomorphin-2 with a beta turn backbone constraint retains the potent mu-opioid receptor agonist properties.
Tomboly, C.; Ballet, S.; Feytens, D.; Kover, K. E.; Borics, A.; Lovas, S.; Al-Khrasani, M.; Furst, Z.; Toth, G.; Benyhe, S.; Tourwe, D., J. Med. Chem. 2008, 51, 173-177.
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