Selected publication list


  • Hendrickx M, Van XH, Leyns L. (2009)
    Anterior-posterior patterning of neural differentiated embryonic stem cells by canonical Wnts, Fgfs, Bmp4 and their respective antagonists.
    Dev Growth Differ. 2009 Aug 23. [Epub ahead of print] - Pubmed
  • Willems E. and L. Leyns “Patterning of mouse embryonic stem cell-derived pan-mesoderm by Activin A/Nodal and Bmp4 signaling requires fibroblast growth factor activity”
    Differentiation 2008, 76:745-59 - Pubmed
  • D. Piette, M. Hendrickx, E. Willems, C. R Kemp and L. Leyns (2008) “ An optimized procedure for whole-mount in situ hybridization on mouse embryos and embryoid bodies”
    Nature Protocols 7: 1194-1201 - Pubmed
  • Hendrickx M. and L. Leyns “Non conventional Frizzled ligands and Wnt receptors”
    Development, Growth & Differentiation, 2008, 50:229-243 - Pubmed
  • Willems E., L. Leyns and J.Vandesompele. 2008 “Standardization of real-time PCR gene expression data from independent biological replicates”
    Analytical Biochemistry 379:127-29 - Pubmed
  • M. Thomas-Chollier, L. Leyns and V. Ledent. “HoxPred: automated classification of Hox proteins using combinations of generalised profiles”
    BMC Bioinformatics 2007, 8:247 - Pubmed
  • C. Kemp, E. Willems, D. Wawrzak, M. Hendrickx, T. Agbor Agbor and L. Leyns “Expression of Frizzleds during early mouse development and interactions with canonical Wnt signaling”
    Developmental Dynamics 2007, 236:2011-9 - Pubmed
  • D. Wawrzak, M. Métioui, E. Willems, M. Hendrickx, E. de Genst and L. Leyns “SFRP1, sFRP2, sFRP4 and Frzb bind Wnt3a in the nanomolar range while only sFRP1 and sFRP2 antagonize Wnt3a activity”
    Biochem Biophys Res Commun. 2007 Jun 15;357(4):1119-23 - Pubmed
  • Kemp C., M. Hendrickx, E. Willems, D. Wawrzak, M. Métioui and L. Leyns 2007 “The Roles of Wnt Signaling in Early Mouse Development and Embryonic Stem Cells”
    Functional Development and Embryology 1(1): 1-13
  • Willems E., Mateizel I., Kemp C., Caufman G., Sermon K. and L. Leyns “Identification of suitable reference genes in mouse and human embryonic stem cell differentiation and in mouse embryonic development”.
    International Journal of Developmental Biology  50(7):627-35, 2006 - Pubmed
  • J. Verheyde, L. de Saint-Georges, L. Leyns and M.A. Benotmane “The role of Trp53 in the transcriptional response to ionizing radiation in the developing brain”
    DNA research  13: 65-75, 2006 - Pubmed
  • C. E. Pierreux, A. V. Poll, C. R. Kemp, F. Clotman, M. A. Maestro, S. Cordi, J. Ferrer, L. Leyns, G. G. Rousseau and F. P. Lemaigre “The transcription factor HNF-6 controls the development of pancreatic ducts and regulates a cystic disease gene network”
    Gastroenterology. 2006 Feb;130(2):532-41. - Pubmed
  • Mannaert A., Roelants K., Bossuyt F. and Leyns L. “A PCR survey for posterior Hox genes in amphibians”.
    Molecular Phylogenetics and Evolution 38:449-458, 2006 - Pubmed
  • Mfopou Kunjom J., Willems E., Leyns L., Bouwens L. “mRNA expression of regulatory genes for pancreas developmentduring murine embryonic stem cell differentiation”.
    Int. J. Dev. Biol. 49: 915-922, 2005 - PubMed
  • C. Kemp, E. Willems, S. Abdo, L. Lambiv and L. Leyns. “Expression of all Wnt genes and their secreted antagonists during mouse blastocyst and postimplantation development. “
    Developmental Dynamics 233: 1064-1075, 2005 - PubMed
  • D.Duprez, L.Leyns, M-A.Bonnin, F.Lapointe, H.Etchevers, E.M. De Robertis and N. Le Douarin. “Expression of Frzb-1 during chick development”
    Mechanism of Development, 89: pp179-183, 1999. - PubMed
  • U.Borello, M.Coletta, S.Tajbakhsh, L.Leyns, E.M. De Robertis, M.Buckingham and G.Cossu. “ Trans-placental delivery of the Wnt antagonist Frzb1 inhibits development of caudal paraxial mesoderm and skeletal myogenesis in mouse embryos.
    Development 126: 4247-4255, 1999. - PubMed
  • S.Piccolo, E.Agius, L.Leyns, S.Bhattacharyya, H.Grunz, T.Bouwmeester and E.M.De Robertis. “The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals.”
    Nature, 397: 707-710, 1999. - PubMed
  • J.A.Belo, L.Leyns, G.Yamada and E.M.De Robertis. “The prechordal midline of the chondrocranium is defective in Goosecoid-1 mouse mutants.”
    Mechanism of Development, 72:15-25, 1998 (+issue cover). - PubMed
  • J.A.Belo, T.Bouwmeester, L.Leyns, N.Kertesz, M.Gallo, M.Folleti and E.M.De Robertis. “Cerberus-like is a secreted factor with neuralizing activity expressed in the anterior primitive endoderm of the mouse gastrula.”
    Mechanism of Development, 68: 45-58, 1997 (+ issue cover). - PubMed
  • Leyns L., T.Bouwmeester, S-H.Kim, S.Piccolo and E.M. De Robertis. “ Frzb-1 is a secreted antagonist of Wnt signaling expressed in Spemann organizer.”
    Cell, 88: 747-756, 1997. - PubMed
  • Leyns L, J-L.Gomez-Skarmeta and C.Dambly-Chaudière. “iroquois; a prepattern gene that controls the formation of bristles on the thorax of Drosophila.”
    Mechanisms of Development 59:63-72, 1996. - PubMed

Review articles.

  • L.Leyns, D.Piette and M. Thomas-Chollier “Evo-Devo: paleontologie zonder fossielen?” (2005), pp125-146 in “Evolutie vandaag” ed. I.Tallon et al – VUBpress.
  • L.Leyns and C.Kemp “Formation and function of the mouse organizer” (2004) Chap 24, pp409-422 in “The vertebrate organizer” ed. H.Gruntz – Springer-Verlag.
  • Kemp C.R., D. Wawrzak, E. Willems, M. Metioui, M. Hendrickx and L. Leyns. “Embryonic Stem cells: from research to therapy” (2004) Human Ecology (Special Issue) 12:49-57
  • T.Bouwmeester and L.Leyns. “Vertebrate head induction by anterior primitive endoderm.”
    Bioessays 19 855-863, 1997.
  • E.M. De Robertis, S.Kim, L.Leyns, S.Piccolo, D.Bachiller, E.Agius, J.A.Belo, A.Yamamoto, A.Hainski-Brousseau, B.Brizuela, O.Wesseley, B.Lu and T.Bouwmeester. “Patterning by genes expressed in Spemann’s organizer” - Cold Spring Harbor symposia on quantitative biology ; v.LXII, 169-175 (1997).



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